Conservation and novelty in the evolution of cell adhesion and extracellular 
matrix genes

Hutter, Harald; Vogel, Bruce E.; Plenefisch, John D.; Norris, Carolyn R.; Proenca, Rui B.; Spieth, John; Guo, Chaobo; Mastwal, Surjeet; Zhu, Xiaoping; Scheel, Jochen; Hedgecock, Edward M.

doi:10.1126/science.287.5455.989

Datensatz

DATENSATZ AKTIONENEXPORT

Zur Ablage hinzufügen

Lokale TagsFreigabegeschichteDetailsÜbersicht

Freigegeben

Zeitschriftenartikel

Conservation and novelty in the evolution of cell adhesion and extracellular matrix genes

MPG-Autoren

/persons/resource/persons93510

Hutter, Harald
Max Planck Research Group Developmental Genetics of the nervous system (Harald Hutter), Max Planck Institute for Medical Research, Max Planck Society;

Externe Ressourcen

http://www.sciencemag.org/cgi/reprint/287/5455/989
(beliebiger Volltext)

http://dx.doi.org/10.1126/science.287.5455.989
(beliebiger Volltext)

Volltexte (beschränkter Zugriff)

Für Ihren IP-Bereich sind aktuell keine Volltexte freigegeben.

Volltexte (frei zugänglich)

Es sind keine frei zugänglichen Volltexte in PuRe verfügbar

Ergänzendes Material (frei zugänglich)

Es sind keine frei zugänglichen Ergänzenden Materialien verfügbar

Zitation

Hutter, H., Vogel, B. E., Plenefisch, J. D., Norris, C. R., Proenca, R. B., Spieth, J., et al. (2000). Conservation and novelty in the evolution of cell adhesion and extracellular matrix genes. Science, 287(5455), 989-994. doi:10.1126/science.287.5455.989.

Zitierlink: https://hdl.handle.net/11858/00-001M-0000-0028-3537-B

Zusammenfassung

New proteins and modules have been invented throughout evolution. Gene birth dates in Caenorhabditis elegans range from the origins of cellular life through adaptation to a soil habitat. Possibly half are metazoan genes, having arisen sometime between the yeast-metazoan and nematode-chordate separations. These include basement membrane and cell adhesion molecules implicated in tissue organization. By contrast, epithelial surfaces facing the environment have specialized components invented within the nematode lineage. Moreover, interstitial matrices were likely elaborated within the vertebrate lineage. A strategy for concerted evolution of new gene families, as well as conservation of adaptive genes, may underlie the differences between heterochromatin and euchromatin.