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Journal Article

DNA-protein crosslink repair

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Stingele,  Julian
Jentsch, Stefan / Molecular Cell Biology, Max Planck Institute of Biochemistry, Max Planck Society;

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Jentsch,  Stefan
Jentsch, Stefan / Molecular Cell Biology, Max Planck Institute of Biochemistry, Max Planck Society;

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Stingele, J., & Jentsch, S. (2015). DNA-protein crosslink repair. NATURE REVIEWS MOLECULAR CELL BIOLOGY, 16(8), 455-460. doi:10.1038/nrm4015.


Cite as: https://hdl.handle.net/11858/00-001M-0000-0028-4638-4
Abstract
DNA-protein crosslinks (DPCs) are highly toxic DNA adducts, but whether dedicated DPC-repair mechanisms exist was until recently unknown. This has changed with discoveries made in yeast and Xenopus laevis that revealed a protease-based DNA-repair pathway specific for DPCs. Importantly, mutations in the gene encoding the putative human homologue of a yeast DPC protease cause a human premature ageing and cancer predisposition syndrome. Thus, DPC repair is a previously overlooked genome-maintenance mechanism that may be essential for tumour suppression.