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Synchronization of the mammalian circadian timing system: Light can control peripheral clocks independently of the SCN clock: Alternate routes of entrainment optimize the alignment of the body's circadian clock network with external time.

MPS-Authors
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Husse,  J. L.
Department of Genes and Behavior, MPI for biophysical chemistry, Max Planck Society;

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Eichele,  G.
Department of Genes and Behavior, MPI for biophysical chemistry, Max Planck Society;

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2182891.pdf
(Publisher version), 775KB

Supplementary Material (public)
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Citation

Husse, J. L., Eichele, G., & Oster, H. (2015). Synchronization of the mammalian circadian timing system: Light can control peripheral clocks independently of the SCN clock: Alternate routes of entrainment optimize the alignment of the body's circadian clock network with external time. BioEssays, 37(10), 1119-1128. doi:10.1002/bies.201500026.


Cite as: http://hdl.handle.net/11858/00-001M-0000-0028-42D5-2
Abstract
A network of cellular circadian clocks adapts physiology to the 24-hour day cycle. Traditionally clock entrainment has been conceptualized in a hierarchical scheme with a light-reset SCN pacemaker that subsequently aligns subordinate peripheral clocks. New experiments suggest that resetting of the circadian system occurs in a more “federated” fashion allowing for increased noise resistance and plasticity of circadian timekeeping under complex natural conditions.