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Journal Article

SPARring with spines

MPS-Authors
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Meyer,  Guido
Molecular neurobiology, Max Planck Institute of Experimental Medicine, Max Planck Society;

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Brose,  Nils
Molecular neurobiology, Max Planck Institute of Experimental Medicine, Max Planck Society;

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Citation

Meyer, G., & Brose, N. (2003). SPARring with spines. Science, 302(5649), 1341-1344. doi:10.1126/science.1092039.


Cite as: https://hdl.handle.net/11858/00-001M-0000-0029-2EBB-7
Abstract
Synaptic plasticity underlies many essential processes in the brain, including learning and memory. In their perspective, Meyer and Brose discuss new work (Pak and Sheng) that elucidates one possible mechanism of use-dependent synaptic plasticity in neurons. This mechanism involves the Snk kinase-induced degradation of the SPAR protein leading to alterations in the morphology of postsynaptic dendritic spines