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Journal Article

Effects of cerebrovascular challenges on plasma endothelin


Ehrenreich,  Hannelore
Clinical neuroscience, Max Planck Institute of Experimental Medicine, Max Planck Society;

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Jordan, W., Decker, M., Kamrowski, H., Brunner, E., Ehrenreich, H., & Hajak, G. (2002). Effects of cerebrovascular challenges on plasma endothelin. Neuroscience Research, 43(2), 127-134.

Cite as: http://hdl.handle.net/11858/00-001M-0000-0029-18D7-B
Plasma endothelin elevations have been associated with cerebrovascular pathology. Mechanisms of stimulation, however, are unknown. Therefore, in healthy subjects a marked physiological cerebrovascular response was experimentally provoked by hypercapnia, hypocapnia, and alternating capneic conditions. During these challenges plasma immunoreactive- endothelin-1 (ir-ET-1) concentrations were determined using a radioimmunassay. Physiological effects were continuously recorded for pCO(2), cerebral blood flow velocity, pulse frequency, and arterial blood pressure. No alterations in plasma ET-1 levels were found upon any of the cerebrovascular stimuli. We conclude that massive cerebrovascular challenges in healthy individuals do not lead to high circulating ET-I levels. (C) 2002 Elsevier Science Ireland Ltd and the Japan Neuroscience Society. All rights reserved.