Help Privacy Policy Disclaimer
  Advanced SearchBrowse




Journal Article

Blood coagulation with domestic deep-seated mycoses


Kratzin,  Hartmut D.
Neurogenetics, Max Planck Institute of Experimental Medicine, Max Planck Society;

External Resource
No external resources are shared
Fulltext (restricted access)
There are currently no full texts shared for your IP range.
Fulltext (public)
There are no public fulltexts stored in PuRe
Supplementary Material (public)
There is no public supplementary material available

Ntefidou, M., Elsner, C., Spreer, A., Weinstock, N., Kratzin, H. D., & Rüchel, R. (2002). Blood coagulation with domestic deep-seated mycoses. Mycoses, 45(Suppl. 1), 53-56.

Cite as: https://hdl.handle.net/11858/00-001M-0000-0029-0A3B-D
Activation of blood coagulation to a varying extent affect the course of domestic invasive mycoses. Upon invasion of blood vessels by Candida or aspergilli, occasionally thrombi are formed, which may cause septic embolism. In the course of mucormycosis (syn. zygomycosis) thrombotic occlusion of afflicted blood vessels and subsequent necrosis of dependent tissue regularly occurs. Coagulation during candidosis or aspergillosis may be triggered by secreted aspartic proteinases which are able to activate factor X as has been shown previously [1, 2]. During mucormycosis, severe blood coagulation apparently is due to paracoagulation of fibrinogen which is triggered by low concentrations of extracellular fungal subtilisin-like proteinase (Arp). The enzyme is also able to inactivate the major inhibitor 4 blood coagulation (antithrombin III). Recent findings on the action of Arp are discussed.