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Journal Article

Structure casts light on mtDNA replication

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Citation

Falkenberg, M., & Larsson, N.-G. (2009). Structure casts light on mtDNA replication. Cell, 139(2), 231-233.


Cite as: http://hdl.handle.net/11858/00-001M-0000-0028-58D0-8
Abstract
In this issue, Lee et al. (2009) present a crystal structure of the human mitochondrial DNA polymerase (POLgamma). The structure of this heterotrimeric enzyme lays a foundation for understanding how POLgamma mutations cause human mitochondrial disease and why some antiviral nucleoside analogs cause cellular toxicity.