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Journal Article

Syntheses and biological evaluation of B-ring-modified analogues of dafachronic acid A

MPS-Authors

Giroux,  S.
Max Planck Society;

Bethke,  A.
Max Planck Society;

Fielenbach,  N.
Max Planck Society;

Antebi,  A.
Max Planck Society;

Corey,  E. J.
Max Planck Society;

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Citation

Giroux, S., Bethke, A., Fielenbach, N., Antebi, A., & Corey, E. J. (2008). Syntheses and biological evaluation of B-ring-modified analogues of dafachronic acid A. Org Lett, 10(16), 3643-5. doi:10.1021/ol801425v.


Cite as: http://hdl.handle.net/11858/00-001M-0000-0028-58EA-0
Abstract
Synthesis and testing of dafachronic acid A ( 1) and its derivatives 2 and 3 have revealed that 1, and not a further oxidation product, is the natural ligand for the DAF-12 receptor of Caenorhabditis elegans.