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Journal Article

Unraveling the biological roles of reactive oxygen species.

MPS-Authors

Murphy, Michael P
Max Planck Society;

Holmgren, Arne
Max Planck Society;

Larsson, Nils-Göran
Max Planck Society;

Halliwell, Barry
Max Planck Society;

Chang, Christopher J
Max Planck Society;

Kalyanaraman, Balaraman
Max Planck Society;

Rhee, Sue Goo
Max Planck Society;

Thornalley, Paul J
Max Planck Society;

Partridge, Linda
Max Planck Society;

Gems, David
Max Planck Society;

Nyström, Thomas
Max Planck Society;

Belousov, Vsevolod
Max Planck Society;

Schumacker, Paul T
Max Planck Society;

Winterbourn, Christine C
Max Planck Society;

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Citation

Murphy, M. P., Holmgren, A., Larsson, N.-G., Halliwell, B., Chang, C. J., Kalyanaraman, B., et al. (2011). Unraveling the biological roles of reactive oxygen species. Cell Metab, 13(4), 361-366.

Abstract

Reactive oxygen species are not only harmful agents that cause oxidative damage in pathologies, they also have important roles as regulatory agents in a range of biological phenomena. The relatively recent development of this more nuanced view presents a challenge to the biomedical research community on how best to assess the significance of reactive oxygen species and oxidative damage in biological systems. Considerable progress is being made in addressing these issues, and here we survey some recent developments for those contemplating research in this area.