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Journal Article

A steroid receptor-microRNA switch regulates life span in response to signals from the gonad

MPS-Authors

Shen,  Y.
Max Planck Society;

Wollam,  J.
Max Planck Society;

Magner,  D.
Max Planck Society;

Karalay,  O.
Max Planck Society;

Antebi,  A.
Max Planck Society;

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Citation

Shen, Y., Wollam, J., Magner, D., Karalay, O., & Antebi, A. (2012). A steroid receptor-microRNA switch regulates life span in response to signals from the gonad. Science, 338(6113), 1472-6. doi:10.1126/science.1228967.


Cite as: http://hdl.handle.net/11858/00-001M-0000-0028-59AE-0
Abstract
Although the gonad primarily functions in procreation, it also affects animal life span. Here, we show that removal of the Caenorhabditis elegans germ line triggers a switch in the regulatory state of the organism to promote longevity, co-opting components involved in larval developmental timing circuits. These components include the DAF-12 steroid receptor, which is involved in the larval stage two-to-stage three (L2-L3) transition and up-regulates members of the let-7 microRNA (miRNA) family. The miRNAs target an early larval nuclear factor lin-14 and akt-1/kinase, thereby stimulating DAF-16/FOXO signaling to extend life. Our studies suggest that metazoan life span is coupled to the gonad through elements of a developmental timer.