English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT

Released

Journal Article

Sterol regulation of metabolism, homeostasis, and development

MPS-Authors

Wollam,  J.
Max Planck Society;

Antebi,  A.
Max Planck Society;

Fulltext (public)
There are no public fulltexts available
Supplementary Material (public)
There is no public supplementary material available
Citation

Wollam, J., & Antebi, A. (2011). Sterol regulation of metabolism, homeostasis, and development. Annu Rev Biochem, 80, 885-916. doi:10.1146/annurev-biochem-081308-165917.


Cite as: http://hdl.handle.net/11858/00-001M-0000-0028-59FD-B
Abstract
Sterol metabolites are critical signaling molecules that regulate metabolism, development, and homeostasis. Oxysterols, bile acids (BAs), and steroids work primarily through cognate sterol-responsive nuclear hormone receptors to control these processes through feed-forward and feedback mechanisms. These signaling pathways are conserved from simple invertebrates to mammals. Indeed, results from various model organisms have yielded fundamental insights into cholesterol and BA homeostasis, lipid and glucose metabolism, protective mechanisms, tissue differentiation, development, reproduction, and even aging. Here, we review how sterols act through evolutionarily ancient mechanisms to control these processes.