Item

ITEM ACTIONS

This item is discarded!DetailsSummary

Discarded

Journal Article

Sterol regulation of metabolism, homeostasis, and development

MPS-Authors

Wollam, J.
Max Planck Society;

Antebi, A.
Max Planck Society;

External Resource

(No access)

Fulltext (restricted access)

There are currently no full texts shared for your IP range.

Fulltext (public)

There are no public fulltexts stored in PuRe

Supplementary Material (public)

There is no public supplementary material available

Citation

Wollam, J., & Antebi, A. (2011). Sterol regulation of metabolism, homeostasis, and development. Annu Rev Biochem, 80, 885-916. doi:10.1146/annurev-biochem-081308-165917.

Abstract

Sterol metabolites are critical signaling molecules that regulate metabolism, development, and homeostasis. Oxysterols, bile acids (BAs), and steroids work primarily through cognate sterol-responsive nuclear hormone receptors to control these processes through feed-forward and feedback mechanisms. These signaling pathways are conserved from simple invertebrates to mammals. Indeed, results from various model organisms have yielded fundamental insights into cholesterol and BA homeostasis, lipid and glucose metabolism, protective mechanisms, tissue differentiation, development, reproduction, and even aging. Here, we review how sterols act through evolutionarily ancient mechanisms to control these processes.