CRIS - a novel cAMP-binding protein controlling spermiogenesis and the 
development of flagellar bending

Krähling, Miriam; Alvarez, Luis; Debowski, K.; Van, Q.; Gunkel, Monika; Irsen, Stephan; Al-Amoudi, A.; Strünker, Timo; Kremmer, E.; Krause, E.; Voigt, I.; Wörtge, S.; Waisman, A.; Weyand, I.; Seifert, Reinhard; Kaupp, Ulrich Benjamin; Wachten, Dagmar

doi:10.1371/journal.pgen.1003960

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CRIS - a novel cAMP-binding protein controlling spermiogenesis and the development of flagellar bending

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/persons/resource/persons182747

Krähling, Miriam
Department of Molecular Sensory Systems, Center of Advanced European Studies and Research (caesar), Max Planck Society;

/persons/resource/persons182717

Alvarez, Luis
Department of Molecular Sensory Systems, Center of Advanced European Studies and Research (caesar), Max Planck Society;

/persons/resource/persons182735

Gunkel, Monika
Department of Molecular Sensory Systems, Center of Advanced European Studies and Research (caesar), Max Planck Society;

/persons/resource/persons182739

Irsen, Stephan
Electron Microscopy and Analytics, Center of Advanced European Studies and Research (caesar), Max Planck Society;

/persons/resource/persons182770

Strünker, Timo
Department of Molecular Sensory Systems, Center of Advanced European Studies and Research (caesar), Max Planck Society;

/persons/resource/persons182767

Seifert, Reinhard
Department of Molecular Sensory Systems, Center of Advanced European Studies and Research (caesar), Max Planck Society;

/persons/resource/persons182743

Kaupp, Ulrich Benjamin
Department of Molecular Sensory Systems, Center of Advanced European Studies and Research (caesar), Max Planck Society;

/persons/resource/persons182737

Wachten, Dagmar
Department of Molecular Sensory Systems, Center of Advanced European Studies and Research (caesar), Max Planck Society;

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https://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1003960
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Citation

Krähling, M., Alvarez, L., Debowski, K., Van, Q., Gunkel, M., Irsen, S., et al. (2013). CRIS - a novel cAMP-binding protein controlling spermiogenesis and the development of flagellar bending. PLoS Genetics, 9(12): e1003960. doi:10.1371/journal.pgen.1003960.

Cite as: https://hdl.handle.net/11858/00-001M-0000-0028-60C1-B

Abstract

The second messengers cAMP and cGMP activate their target proteins by binding to a conserved cyclic nucleotide-binding domain (CNBD). Here, we identify and characterize an entirely novel CNBD-containing protein called CRIS (cyclic nucleotide receptor involved in sperm function) that is unrelated to any of the other members of this protein family. CRIS is exclusively expressed in sperm precursor cells. Cris-deficient male mice are either infertile due to a lack of sperm resulting from spermatogenic arrest, or subfertile due to impaired sperm motility. The motility defect is caused by altered Ca2+ regulation of flagellar beat asymmetry, leading to a beating pattern that is reminiscent of sperm hyperactivation. Our results suggest that CRIS interacts during spermiogenesis with Ca2+-regulated proteins that—in mature sperm—are involved in flagellar bending.