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Cooperative and uncooperative cyclic-nucleotide-gated ion channels

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Cukkemane,  A.
Department of Molecular Sensory Systems, Center of Advanced European Studies and Research (caesar), Max Planck Society;

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Seifert,  R.
Department of Molecular Sensory Systems, Center of Advanced European Studies and Research (caesar), Max Planck Society;

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Kaupp,  U. B.
Department of Molecular Sensory Systems, Center of Advanced European Studies and Research (caesar), Max Planck Society;

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Citation

Cukkemane, A., Seifert, R., & Kaupp, U. B. (2011). Cooperative and uncooperative cyclic-nucleotide-gated ion channels. Trends in Biochemical Sciences, 36(1), 55-64.


Cite as: http://hdl.handle.net/11858/00-001M-0000-0028-61FD-0
Abstract
Ion channels gated by cyclic nucleotides serve multiple functions in sensory signaling in diverse cell types ranging from neurons to sperm. Newly discovered members from bacteria and marine invertebrates provide a wealth of structural and functional information on this channel family. A hallmark of classical tetrameric cyclic-nucleotide-gated channels is their cooperative activation by binding of several ligands. By contrast, the new members seem to be uncooperative, and binding of a single ligand molecule suffices to open these channels. These new findings provide a fresh look at the mechanism of allosteric activation of ion channels