A novel family of structurally stable double stranded DNA catenanes

Lohmann, F.; Valero, J.; Famulok, M.

doi:10.1039/c4cc02030h

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A novel family of structurally stable double stranded DNA catenanes

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http://www.ncbi.nlm.nih.gov/pubmed/24777123
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http://pubs.rsc.org/en/Content/ArticleLanding/2014/CC/c4cc02030h
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Lohmann, F., Valero, J., & Famulok, M. (2014). A novel family of structurally stable double stranded DNA catenanes. Chemical communications, 50(46), 6091-3. doi:10.1039/c4cc02030h.

Cite as: https://hdl.handle.net/11858/00-001M-0000-0028-63E5-5

Abstract

Here we describe the design, assembly and characterisation of different structurally stable and highly polyvalent DNA catenanes. We synthesized a series of different catenated DNA nanostructures, among them symmetric ones containing two 126 or 168 base-pair rings, non-symmetric ones with a 126 and a 168 base-pair ring, and a [3]catenane containing three 126 base-pair rings. Reversible and quantitative on/off switching of the mobility of the rings was demonstrated as a proof-of-concept for the employment of these catenanes as dynamic DNA-nanostructures.