Repression of the genome organizer SATB1 in regulatory T cells is required for 
suppressive function and inhibition of effector differentiation

Beyer, M.; Thabet, Y.; Müller, R. U.; Sadlon, T.; Classen, S.; Lahl, K.; Basu, S.; Zhou, X.; Bailey-Bucktrout, S. L.; Krebs, W.; Schönfeld, E. A.; Böttcher, J.; Golovina, T.; Mayer, C. T.; Hofmann, A.; Sommer, D.; Debey-Pascher, S.; Endl, E.; Limmer, A.; Hippen, K. L.; Blazar, B. R.; Balderas, R.; Quast, T.; Waha, A.; Mayer, G.; Famulok, M.; Knolle, P. A.; Wickenhauser, C.; Kolanus, W.; Schermer, B.; Bluestone, J. A.; Barry, S. C.; Sparwasser, T.; Riley, J. L.; Schultze, J. L.

doi:10.1038/ni.2084

Datensatz

DATENSATZ AKTIONENEXPORT

Zur Ablage hinzufügen

Lokale TagsFreigabegeschichteDetailsÜbersicht

Freigegeben

Zeitschriftenartikel

Repression of the genome organizer SATB1 in regulatory T cells is required for suppressive function and inhibition of effector differentiation

MPG-Autoren

Es sind keine MPG-Autoren in der Publikation vorhanden

Externe Ressourcen

http://www.ncbi.nlm.nih.gov/pubmed/21841785
(beliebiger Volltext)

http://www.nature.com/ni/journal/v12/n9/pdf/ni.2084.pdf
(beliebiger Volltext)

Volltexte (beschränkter Zugriff)

Für Ihren IP-Bereich sind aktuell keine Volltexte freigegeben.

Volltexte (frei zugänglich)

Es sind keine frei zugänglichen Volltexte in PuRe verfügbar

Ergänzendes Material (frei zugänglich)

Es sind keine frei zugänglichen Ergänzenden Materialien verfügbar

Zitation

Beyer, M., Thabet, Y., Müller, R. U., Sadlon, T., Classen, S., Lahl, K., et al. (2011). Repression of the genome organizer SATB1 in regulatory T cells is required for suppressive function and inhibition of effector differentiation. Nature Immunology, 12(9), 898-907. doi:10.1038/ni.2084.

Zitierlink: https://hdl.handle.net/11858/00-001M-0000-0028-642C-0

Zusammenfassung

Regulatory T cells (T(reg) cells) are essential for self-tolerance and immune homeostasis. Lack of effector T cell (T(eff) cell) function and gain of suppressive activity by T(reg) cells are dependent on the transcriptional program induced by Foxp3. Here we report that repression of SATB1, a genome organizer that regulates chromatin structure and gene expression, was crucial for the phenotype and function of T(reg) cells. Foxp3, acting as a transcriptional repressor, directly suppressed the SATB1 locus and indirectly suppressed it through the induction of microRNAs that bound the SATB1 3' untranslated region. Release of SATB1 from the control of Foxp3 in T(reg) cells caused loss of suppressive function, establishment of transcriptional T(eff) cell programs and induction of T(eff) cell cytokines. Our data support the proposal that inhibition of SATB1-mediated modulation of global chromatin remodeling is pivotal for maintaining T(reg) cell functionality.