Deutsch
 
Hilfe Datenschutzhinweis Impressum
  DetailsucheBrowse

Datensatz

DATENSATZ AKTIONENEXPORT
Zur Ablage hinzufügen
  Lokale TagsFreigabegeschichteDetailsÜbersicht

Freigegeben
Zeitschriftenartikel

Variants of the protein PRDM9 differentially regulate a set of human meiotic recombination hotspots highly active in African populations

MPG-Autoren
Es sind keine MPG-Autoren in der Publikation vorhanden
Externe Ressourcen
Es sind keine externen Ressourcen hinterlegt
Volltexte (beschränkter Zugriff)
Für Ihren IP-Bereich sind aktuell keine Volltexte freigegeben.
Volltexte (frei zugänglich)
Es sind keine frei zugänglichen Volltexte in PuRe verfügbar
Ergänzendes Material (frei zugänglich)
Es sind keine frei zugänglichen Ergänzenden Materialien verfügbar
Zitation

Berg, I. L., Neumann, R., Sarbajna, S., Odenthal-Hesse, L., Butler, N. J., & Jeffreys, a. A. J. (2011). Variants of the protein PRDM9 differentially regulate a set of human meiotic recombination hotspots highly active in African populations. Proceedings of the National Academy of Sciences of the United States of America, 108(30), 12378-12383. doi:10.1073/pnas.1109531108.


Zitierlink: https://hdl.handle.net/11858/00-001M-0000-0028-63D2-D
Zusammenfassung
PRDM9 is a major specifier of human meiotic recombination
hotspots, probably via binding of its zinc-finger repeat array to
a DNA sequence motif associated with hotspots. However, our
viewof PRDM9 regulation, in terms ofmotifs defined and hotspots
studied, has a strong bias toward the PRDM9 A variant particularly
common in Europeans. We show that population diversity can
reveal a second class of hotspots specifically activated by PRDM9
variants common in Africans but rare in Europeans. These Africanenhanced
hotspots nevertheless share very similar propertieswith
their counterparts activated by the A variant. The specificity of
hotspot activation is such that individuals with differing PRDM9
genotypes, evenwithin the same population, can use substantially
if not completely different sets of hotspots. Each African-enhanced
hotspot is activated by a distinct spectrum of PRDM9 variants,
despite the fact that all are predicted to bind the same
sequence motif. This differential activation points to complex
interactions between the zinc-finger array and hotspots and identifies
features of the array that might be important in controlling
hotspot activity.