English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT

Released

Journal Article

Integrating mitochondrial translation into the cellular context.

MPS-Authors
There are no MPG-Authors available
Fulltext (public)
There are no public fulltexts available
Supplementary Material (public)

2214844_Suppl.pdf
(Supplementary material), 278KB

Citation

Richter-Dennerlein, R., Dennerlein, S., & Rehling, P. (2015). Integrating mitochondrial translation into the cellular context. Nature Reviews Molecular Cell Biology, 16(10), 586-592. doi:10.1038/nrm4051.


Cite as: http://hdl.handle.net/11858/00-001M-0000-0028-937C-6
Abstract
Mitochondrial-encoded subunits of the oxidative phosphorylation system assemble with nuclear-encoded subunits into enzymatic complexes. Recent findings showed that mitochondrial translation is linked to other mitochondrial functions, as well as to cellular processes. The supply of mitochondrial- encoded proteins is coordinated by the coupling of mitochondrial protein synthesis with assembly of respiratory chain complexes. MicroRNAs imported from the cytoplasm into mitochondria were, surprisingly, found to act as regulators of mitochondrial translation. In turn, translation in mitochondria controls cellular proliferation, and mitochondrial ribosomal subunits contribute to the cytoplasmic stress response. Thus, translation in mitochondria is apparently integrated into cellular processes.