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SMC condensin: promoting cohesion of replicon arms

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Bürmann,  Frank
Gruber, Stephan / Chromosome Organization and Dynamics, Max Planck Institute of Biochemistry, Max Planck Society;

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Gruber,  Stephan
Gruber, Stephan / Chromosome Organization and Dynamics, Max Planck Institute of Biochemistry, Max Planck Society;

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Citation

Bürmann, F., & Gruber, S. (2015). SMC condensin: promoting cohesion of replicon arms. NATURE STRUCTURAL & MOLECULAR BIOLOGY, 22(9), 653-655. doi:10.1038/nsmb.3082.


Cite as: http://hdl.handle.net/11858/00-001M-0000-0028-9510-8
Abstract
Two studies using chromosome conformation capture (3C) analyses in the Gram-positive bacterium Bacillus subtilis have revealed a global pattern of chromosome organization that originates from loading sites of the Smc-ScpAB complex. Loading Smc-ScpAB at a single genomic location is sufficient to promote genome-wide folding of DNA into a well-defined structure.