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Understanding morphogenetic growth control - lessons from flies

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Mumcu,  P.
Max Planck Institute for the Physics of Complex Systems, Max Planck Society;

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Julicher,  F.
Max Planck Institute for the Physics of Complex Systems, Max Planck Society;

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Citation

Wartlick, O., Mumcu, P., Julicher, F., & Gonzalez-Gaitan, M. (2011). Understanding morphogenetic growth control - lessons from flies. Nature Reviews Molecular Cell Biology, 12(9), 594-604.


Cite as: https://hdl.handle.net/11858/00-001M-0000-0029-8C39-8
Abstract
Morphogens are secreted signalling molecules that control the patterning and growth of developing organs. How morphogens regulate patterning is fairly well understood; however, how they control growth is less clear. Four principal models have been proposed to explain how the morphogenetic protein Decapentaplegic ( DPP) controls the growth of the wing imaginal disc in the fly. Recent studies in this model system have provided a wealth of experimental data on growth and DPP gradient properties, as well as on the interactions of DPP with other signalling pathways. These findings have allowed a more precise formulation and evaluation of morphogenetic growth models. The insights into growth control by the DPP gradient will also be useful for understanding other morphogenetic growth systems.