Conditional restoration of hippocampal synaptic potentiation in 
GluR-A-deficient mice

Mack, Volker; Burnashev, Nail; Kaiser, Katharina; Rozov, Andrej; Jensen, Vidar; Hvalby, Øivind; Seeburg, Peter H.; Sakmann, Bert; Sprengel, Rolf

doi:10.1126/science.1059365

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Conditional restoration of hippocampal synaptic potentiation in GluR-A-deficient mice

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Mack, Volker
Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Max Planck Society;

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Burnashev, Nail
Department of Cell Physiology, Max Planck Institute for Medical Research, Max Planck Society;

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Kaiser, Katharina
Department of Cell Physiology, Max Planck Institute for Medical Research, Max Planck Society;

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Rozov, Andrej
Department of Cell Physiology, Max Planck Institute for Medical Research, Max Planck Society;
Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Max Planck Society;

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Seeburg, Peter H.
Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Max Planck Society;

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Sakmann, Bert
Department of Cell Physiology, Max Planck Institute for Medical Research, Max Planck Society;

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Sprengel, Rolf
Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Max Planck Society;

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http://www.sciencemag.org/cgi/reprint/292/5526/2501
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http://dx.doi.org/10.1126/science.1059365
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Citation

Mack, V., Burnashev, N., Kaiser, K., Rozov, A., Jensen, V., Hvalby, Ø., et al. (2001). Conditional restoration of hippocampal synaptic potentiation in GluR-A-deficient mice. Science, 292(5526), 2501-2504. doi:10.1126/science.1059365.

Cite as: https://hdl.handle.net/11858/00-001M-0000-0028-F79F-7

Abstract

Plasticity of mature hippocampal CA1 synapses is dependent on l-alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate (AMPA) receptors containing the glutamate receptor A (GluR-A) subunit. In GluR-A-deficient mice, plasticity could be restored by controlled expression of green fluorescent protein (GFP)-tagged GluR-A, which contributes to channel formation and displayed the developmental redistribution of AMPA receptors in CA1 pyramidal neurons. Long-term potentiation (LTP) induced by pairing or tetanic stimulation was rescued in adult GluR-A(-/-) mice when (GFP)GluR-A expression was constitutive or induced in already fully developed pyramidal cells. This shows that GluR-A-independent forms of synaptic plasticity can mediate the establishment of mature hippocampal circuits that are prebuilt to express GluR-A-dependent LTP.