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Functional classification of memory CD8(+) T cells by CX(3)CR1 expression

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Meissner,  Felix
Meissner, Felix / Experimental Systems Immunology, Max Planck Institute of Biochemistry, Max Planck Society;

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Rieckmann,  Jan C.
Mann, Matthias / Proteomics and Signal Transduction, Max Planck Institute of Biochemistry, Max Planck Society;

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Citation

Böttcher, J. P., Beyer, M., Meissner, F., Abdullah, Z., Sander, J., Höchst, B., et al. (2015). Functional classification of memory CD8(+) T cells by CX(3)CR1 expression. NATURE COMMUNICATIONS, 6: 8306. doi:10.1038/ncomms9306.


Cite as: http://hdl.handle.net/11858/00-001M-0000-0029-089A-7
Abstract
Localization of memory CD8(+) T cells to lymphoid or peripheral tissues is believed to correlate with proliferative capacity or effector function. Here we demonstrate that the fractalkine-receptor/CX(3)CR1 distinguishes memory CD8(+) T cells with cytotoxic effector function from those with proliferative capacity, independent of tissue-homing properties. CX(3)CR1-based transcriptome and proteome-profiling defines a core signature of memory CD8(+) T cells with effector function. We find CD62L(hi)CX(3)CR1(+) memory T cells that reside within lymph nodes. This population shows distinct migration patterns and positioning in proximity to pathogen entry sites. Virus-specific CX(3)CR1(+) memory CD8(+) T cells are scarce during chronic infection in humans and mice but increase when infection is controlled spontaneously or by therapeutic intervention. This CX3CR1-based functional classification will help to resolve the principles of protective CD8(+) T-cell memory.