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Glutamate receptor channel signatures

MPS-Authors
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Sprengel,  Rolf
Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Max Planck Society;

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Aronoff,  Rachel
Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Max Planck Society;

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Kuner,  Thomas
Interdisciplinary WIN-Research Group on Olfactory Dynamics, Max Planck Institute for Medical Research, Max Planck Society;
Synaptic Transmission MNTB, Max Planck Institute for Medical Research, Max Planck Society;
Synaptic Transmission, Max Planck Institute for Medical Research, Max Planck Society;
Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Max Planck Society;
Department of Cell Physiology, Max Planck Institute for Medical Research, Max Planck Society;

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Citation

Sprengel, R., Aronoff, R., Völkner, M., Schmitt, B., Mosbach, R., & Kuner, T. (2001). Glutamate receptor channel signatures. Trends in Pharmacological Sciences, 22(1), 7-10. doi:10.1016/S0165-6147(00)01588-1.


Cite as: http://hdl.handle.net/11858/00-001M-0000-0029-2318-2
Abstract
Genes encoding glutamate receptor channel subunits were identified in genomes from Drosophila melanogaster and Caenorhabditis elegans by homology search with amino acid sequences that participate in the conserved channel pore. The predicted sequences of the putative glutamate receptor subunits revealed a distinct channel pore signature for each receptor subtype and for most of them, related members were found in C. elegans and Drosophila.