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Type II toxin: antitoxin systems. More than small selfish entities?

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Rocker,  Andrea
Department of Biomolecular Mechanisms, Max Planck Institute for Medical Research, Max Planck Society;

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Meinhart,  Anton
Department of Biomolecular Mechanisms, Max Planck Institute for Medical Research, Max Planck Society;

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Citation

Rocker, A., & Meinhart, A. (2016). Type II toxin: antitoxin systems. More than small selfish entities? Current Genetics, 62(2), 287-290. doi:10.1007/s00294-015-0541-7.


Cite as: http://hdl.handle.net/11858/00-001M-0000-0029-2E7E-2
Abstract
Toxin-antitoxin (TA) modules regulate metabolism and viability of bacteria and archaea. In type II TA systems these functions are generally thought to be performed by two small proteins. However, evidence is increasing that the toxins are much more diverse and can form multi-domain proteins. Recently, we published a novel type II TA system in which toxin and antitoxin are covalently linked into a single polypeptide chain. In this review we summarize the current knowledge on these elongated toxin homologs and provide perspectives for future study.