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Journal Article

Biomarker in der Depressionsbehandlung: mehr als nur Worte? [Biomarkers in clinical depression treatment: more than words?]


Breitenstein,  Barbara
Max Planck Institute of Psychiatry, Max Planck Society;

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Bosch, O. G., & Breitenstein, B. (2015). Biomarker in der Depressionsbehandlung: mehr als nur Worte? [Biomarkers in clinical depression treatment: more than words?]. ZEITSCHRIFT FUR PSYCHIATRIE PSYCHOLOGIE UND PSYCHOTHERAPIE, 63(4), 217-232. doi:10.1024/1661-4747/a000244.

Cite as: https://hdl.handle.net/11858/00-001M-0000-0029-B02D-3
Diagnosis of depression relies on categorical classification systems, encompassing heterogeneous and partly opposing symptoms with still unresolved pathophysiology. However, the diagnostic process and the treatment selection still occur exclusively by means of verbal communication. To date, characterization of pathophysiology and treatment mechanisms in depression using biomarkers and genetic testing promises a more valid and thus more effective therapy management. At present, diverse methods such as genetic testing, proteomic and metabolomic profiling, neuroendocrine and electrophysiological parameters, and multimodal neuroimaging, have revealed first potentially useful biomarkers of depression. From some of these, biological models of depression have been established, involving the diathesis-stress model, the serotonin model, and frontocingulate dysfunction model of depression. To date, guidelines which integrate objectively assessable biomarkers into regular clinical depression treatment are still lacking. Until laboratory data, i.e. gene tests and biomarkers find their way into clinical practice, language will have the final say in depression treatment.