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Peak flow velocities in the ascending aorta-real-time phase-contrast magnetic resonance imaging vs. cine magnetic resonance imaging and echocardiography.

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Joseph,  A. A.
Biomedical NMR Research GmbH, MPI for biophysical chemistry, Max Planck Society;

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Merboldt,  K. D.
Biomedical NMR Research GmbH, MPI for biophysical chemistry, Max Planck Society;

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Voit,  D.
Biomedical NMR Research GmbH, MPI for biophysical chemistry, Max Planck Society;

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Frahm,  J.
Biomedical NMR Research GmbH, MPI for biophysical chemistry, Max Planck Society;

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Citation

Sohns, J. M., Kowallick, J. T., Joseph, A. A., Merboldt, K. D., Voit, D., Fasshauer, M., et al. (2015). Peak flow velocities in the ascending aorta-real-time phase-contrast magnetic resonance imaging vs. cine magnetic resonance imaging and echocardiography. Quantitative Imaging in Medicine and Surgery, 5(5), 685-690. doi:10.3978/j.issn.2223-4292.2015.08.08.


Cite as: http://hdl.handle.net/11858/00-001M-0000-0029-4497-B
Abstract
This prospective study of eight healthy volunteers evaluates peak flow velocities (PFV) in the ascending aorta using real-time phase-contrast magnetic resonance imaging (MRI) in comparison to cine phase-contrast MRI and echocardiography. Flow measurements by echocardiography and cine phase-contrast MRI with breath-holding were performed according to clinical standards. Real-time phase-contrast MRI at 40 ms temporal resolution and 1.3 mm in-plane resolution was based on highly undersampled radial fast low-angle shot (FLASH) sequences with image reconstruction by regularized nonlinear inversion (NLINV). Evaluations focused on the determination of PFV. Linear regressions and Bland-Altman plots were used for comparisons of methods. When averaged across subjects, real-time phase-contrast MRI resulted in PFV of 120±20 cm s(-1) (mean ± SD) in comparison to 122±16 cm s(-1) for cine MRI and 124±20 cm s(-1) for echocardiography. The maximum deviations between real-time phase-contrast MRI and echocardiography ranged from -20 to +14 cm s(-1) (cine MRI: -10 to +12 cm s(-1)). Thus, in general, real-time phase-contrast MRI of cardiac outflow revealed quantitative agreement with cine MRI and echocardiography. The advantages of real-time MRI are measurements during free breathing and access to individual cardiac cycles.