English
 
User Manual Privacy Policy Disclaimer Contact us
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT

Released

Journal Article

Pax6 inactivation in the adult pancreas reveals ghrelin as endocrine cell maturation marker.

MPS-Authors
/persons/resource/persons98146

Ahmad,  Z.
Research Group of Molecular Cell Differentiation, MPI for Biophysical Chemistry, Max Planck Society;

/persons/resource/persons15488

Mansouri,  A.
Research Group of Molecular Cell Differentiation, MPI for Biophysical Chemistry, Max Planck Society;

Fulltext (public)

2241298.pdf
(Publisher version), 32MB

Supplementary Material (public)
There is no public supplementary material available
Citation

Ahmad, Z., Rafeeq, M., Collombat, P., & Mansouri, A. (2015). Pax6 inactivation in the adult pancreas reveals ghrelin as endocrine cell maturation marker. PLoS One, 10(12): e0144597. doi: 10.1371/journal.pone.0144597.


Cite as: http://hdl.handle.net/11858/00-001M-0000-0029-4E1C-2
Abstract
The transcription factor Pax6 is an important regulator of development and cell differentiation in various organs. Thus, Pax6 was shown to promote neural development in the cerebral cortex and spinal cord, and to control pancreatic endocrine cell genesis. However, the role of Pax6 in distinct endocrine cells of the adult pancreas has not been addressed. We report the conditional inactivation of Pax6 in insulin and glucagon producing cells of the adult mouse pancreas. In the absence of Pax6, beta- and alpha-cells lose their molecular maturation characteristics. Our findings provide strong evidence that Pax6 is responsible for the maturation of beta-, and alpha-cells, but not of delta-, and PP-cells. Moreover, lineage-tracing experiments demonstrate that Pax6-deficient beta- and alpha-cells are shunted towards ghrelin marked cells, sustaining the idea that ghrelin may represent a marker for endocrine cell maturation.