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Inducible and combinatorial gene manipulation in mouse brain

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Dogbevia,  Godwin
Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Max Planck Society;

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Bausen,  Melanie
Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Max Planck Society;

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Sprengel,  Rolf
Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Max Planck Society;

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Hasan,  Mazahir T.
Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Max Planck Society;

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Citation

Dogbevia, G., Marticorena-Alvarez, R., Bausen, M., Sprengel, R., & Hasan, M. T. (2015). Inducible and combinatorial gene manipulation in mouse brain. Frontiers in Cellular Neuroscience, 9: 142. doi:10.3389/fncel.2015.00142.


Cite as: https://hdl.handle.net/11858/00-001M-0000-0029-5683-6
Abstract
We have deployed recombinant adeno-associated viruses equipped with tetracycline-controlled genetic switches to manipulate gene expression in mouse brain. Here, we show a combinatorial genetic approach for inducible, cell type-specific gene expression and Cre/loxP mediated gene recombination in different brain regions. Our chemical-genetic approach will help to investigate ‘when’, ‘where’, and ‘how’ gene(s) control neuronal circuit dynamics, and organize, for example, sensory signal processing, learning and memory, and behavior.