Raising the speed limit – fast Ca2+ handling in dendritic spines

Helmchen, Fritjof

doi:10.1016/S0166-2236(02)02232-4

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Raising the speed limit – fast Ca2+ handling in dendritic spines

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Helmchen, Fritjof
Department of Cell Physiology, Max Planck Institute for Medical Research, Max Planck Society;

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http://www.sciencedirect.com/science/article/pii/S0166223602022324/pdfft?md5=d2a2c34cc884fbdb8a800973fff04ac9&pid=1-s2.0-S0166223602022324-main.pdf
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http://dx.doi.org/10.1016/S0166-2236(02)02232-4
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Citation

Helmchen, F. (2002). Raising the speed limit – fast Ca2+ handling in dendritic spines. Trends in Neurosciences, 25(9), 438-441. doi:10.1016/S0166-2236(02)02232-4.

Cite as: https://hdl.handle.net/11858/00-001M-0000-0029-61A1-D

Abstract

Ca2+ influx into dendritic spines is involved in the induction of both long-term potentiation (LTP) and long-term depression (LTD) by activating distinct biochemical cascades, depending on the stimulation protocol. Such conditional activation can be explained by the finding that removal of Ca2+ from spines is extremely rapid (~15 ms) and promoted by a low endogenous buffering capacity. As a consequence, the time course of influx and binding kinetics are important determinants of how much Ca2+ binds to a particular enzyme. In addition structural factors, such as shape and dendritic location, could contribute to fine-tuning of spine Ca2+ handling and synaptic modification.