The use of a combination of RDC and chiroptical spectroscopy for determination 
of the absolute configuration of fusariumin A from the fungus Fusarium sp.

Liu, L. Y.; Sun, H.; Griesinger, C.; Liu, J. K.

doi:10.1007/s13659-015-0084-0

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The use of a combination of RDC and chiroptical spectroscopy for determination of the absolute configuration of fusariumin A from the fungus Fusarium sp.

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Sun, H.
Department of NMR Based Structural Biology, MPI for biophysical chemistry, Max Planck Society;

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Griesinger, C.
Department of NMR Based Structural Biology, MPI for biophysical chemistry, Max Planck Society;

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Citation

Liu, L. Y., Sun, H., Griesinger, C., & Liu, J. K. (2016). The use of a combination of RDC and chiroptical spectroscopy for determination of the absolute configuration of fusariumin A from the fungus Fusarium sp. Natural Products and Bioprospecting, 6(1), 41-48. doi:10.1007/s13659-015-0084-0.

Cite as: https://hdl.handle.net/11858/00-001M-0000-0029-6AA9-6

Abstract

A new alkylpyrrole derivative, fusariumin A (1), was isolated from the culture broth of the fungus Fusarium sp. The absolute configuration of fuasiumin A has been established as (2'R,3'R) using a combination of RDC (residual dipolar coupling)-based NMR and DFT-supported chiroptical spectroscopy. It is worth to note that in this study without the aid of the RDC analysis, an unambiguous determination of configuration and conformation was not feasible due to the excessive conformational possibilities of this open-chain compound.