Protein Phosphorylation: A Major Switch Mechanism for Metabolic Regulation

Humphrey, Sean J.; James, David E.; Mann, Matthias

doi:10.1016/j.tem.2015.09.013

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Protein Phosphorylation: A Major Switch Mechanism for Metabolic Regulation

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Humphrey, Sean J.
Mann, Matthias / Proteomics and Signal Transduction, Max Planck Institute of Biochemistry, Max Planck Society;

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Mann, Matthias
Mann, Matthias / Proteomics and Signal Transduction, Max Planck Institute of Biochemistry, Max Planck Society;

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Humphrey, S. J., James, D. E., & Mann, M. (2015). Protein Phosphorylation: A Major Switch Mechanism for Metabolic Regulation. TRENDS IN ENDOCRINOLOGY AND METABOLISM, 26(12; Special Issue: Systems Approach to Metabolic Disease), 676-687. doi:10.1016/j.tem.2015.09.013.

Cite as: https://hdl.handle.net/11858/00-001M-0000-0029-7295-3

Abstract

Metabolism research is undergoing a renaissance because many diseases are increasingly recognized as being characterized by perturbations in intracellular metabolic regulation. Metabolic changes can be conferred through changes to the expression of metabolic enzymes, the concentrations of substrates or products that govern reaction kinetics, or post-translational modification (PTM) of the proteins that facilitate these reactions. On the 60th anniversary since its discovery, reversible protein phosphorylation is widely appreciated as an essential PTM regulating metabolism. With the ability to quantitatively measure dynamic changes in protein phosphorylation on a global scale - hereafter referred to as phosphoproteomics - we are now entering a new era in metabolism research, with mass spectrometry (MS)-based proteomics at the helm.