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Journal Article

The inner workings of AMPA receptors


Madden,  Dean R.
Max Planck Research Group Ion Channel Structure (Dean R. Madden), Max Planck Institute for Medical Research, Max Planck Society;

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Madden, D. R. (2002). The inner workings of AMPA receptors. Current Opinion in Drug Discovery Development, 5(5), 741-748. Retrieved from http://www.biomedcentral.com/pubmed/12630294.

Cite as: http://hdl.handle.net/11858/00-001M-0000-0029-71BB-8
As with all ligand-gated ion channels, ionotropic glutamate receptors (iGluRs) convert the free energy of agonist-binding into a sequence of conformational changes that allow regulated ion flux across an otherwise insulating membrane bilayer. In the case of iGluRs, the resulting membrane depolarization is a key mediator of intercellular signals in the synapses of the CNS. Recent biomedical and structural research has greatly expanded our understanding of the chemistry of iGluR agonist binding, and of the subsequent molecular changes that drive channel gating and desensitization.