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Baseline oxygenation in the brain: Correlation between respiratory-calibration and susceptibility methods

MPS-Authors

Fan,  Audrey P.
Department Neurophysics (Weiskopf), MPI for Human Cognitive and Brain Sciences, Max Planck Society;
Richard M. Lucas Service Center for Imaging, Stanford University, CA, USA;

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Schäfer,  Andreas
Department Neurophysics (Weiskopf), MPI for Human Cognitive and Brain Sciences, Max Planck Society;

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Huber,  Laurentius
Methods and Development Unit Nuclear Magnetic Resonance, MPI for Human Cognitive and Brain Sciences, Max Planck Society;

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Lampe,  Leonie
Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society;

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von Smuda,  Steffen
Methods and Development Unit Nuclear Magnetic Resonance, MPI for Human Cognitive and Brain Sciences, Max Planck Society;

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Möller,  Harald E.
Methods and Development Unit Nuclear Magnetic Resonance, MPI for Human Cognitive and Brain Sciences, Max Planck Society;

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Villringer,  Arno
Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society;

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Gauthier,  Claudine
Department Neurology, MPI for Human Cognitive and Brain Sciences, Max Planck Society;
Concordia University, Montréal, QC, Canada;

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Citation

Fan, A. P., Schäfer, A., Huber, L., Lampe, L., von Smuda, S., Möller, H. E., et al. (2016). Baseline oxygenation in the brain: Correlation between respiratory-calibration and susceptibility methods. NeuroImage, 125, 920-931. doi:10.1016/j.neuroimage.2015.11.007.


Cite as: http://hdl.handle.net/11858/00-001M-0000-0029-79E5-C
Abstract
New MRI methods for noninvasive imaging of baseline oxygen extraction fraction (OEF) in the brain show great promise. Quantitative O2 imaging (QUO2) applies a biophysical model to measure OEF in tissue from BOLD, cerebral blood flow (CBF), and end-tidal O2 (ETO2) signals acquired during two or more gas manipulations. Alternatively, quantitative susceptibility mapping (QSM) maps baseline OEF along cerebral vessels based on the deoxyhemoblogin (dHb) susceptibility shift between veins and water. However, these approaches have not been carefully compared to each other or to known physiological signals. The aims of this study were to compare OEF values by QUO2 and QSM; and to see if baseline OEF relates to BOLD and CBF changes during a visual task. Simultaneous BOLD and arterial spin labeling (ASL) scans were acquired at 7 T in 11 healthy subjects continuously during hypercapnia (5% CO2, 21% O2), hyperoxia (100% O2), and carbogen (5% CO2, 95% O2) for QUO2 analysis. Separate BOLD-ASL scans were acquired during a checkerboard stimulus to identify functional changes in the visual cortex. Gradient echo phase images were also collected at rest for QSM reconstruction of OEF along cerebral veins draining the visual cortex. Mean baseline OEF was (43.5 ± 14)% for QUO2 with two gases, (42.3 ± 17)% for QUO2 with three gases, and (29.4 ± 3)% for QSM across volunteers. Three-gas QUO2 values of OEF correlated with QSM values of OEF (P = 0.03). However, Bland–Altman analysis revealed that QUO2 tended to measure higher baseline OEF with respect to QSM, which likely results from underestimation of the hyperoxic BOLD signal and low signal-to-noise ratio of the ASL acquisitions. Across subjects, the percent CBF change during the visual task correlated with OEF measured by 3-gas QUO2 (P < 0.04); and by QSM (P = 0.035), providing evidence that the new methods measure true variations in brain physiology across subjects.