Rekonstitution biologischer Selbstorganisation in vitro

Kretschmer, Simon; Schwille, Petra

doi:10.1007/s12268-015-0550-6

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Rekonstitution biologischer Selbstorganisation in vitro

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Kretschmer, Simon
Schwille, Petra / Cellular and Molecular Biophysics, Max Planck Institute of Biochemistry, Max Planck Society;

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Schwille, Petra
Schwille, Petra / Cellular and Molecular Biophysics, Max Planck Institute of Biochemistry, Max Planck Society;

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Citation

Kretschmer, S., & Schwille, P. (2015). Rekonstitution biologischer Selbstorganisation in vitro. Biospektrum, 21(2), 148-150. doi:10.1007/s12268-015-0550-6.

Cite as: https://hdl.handle.net/11858/00-001M-0000-0029-AA09-F

Abstract

The Escherichia coli Min proteins select the cell middle for division by oscillating between the cell poles where they inhibit the divisome protein FtsZ. Reconstitution of Min proteins on a lipid membrane in vitro yields their self-organization into surface waves. In biomimetic compartments, pole-to-pole oscillations can be obtained which direct FtsZ to the middle. This establishes bottom-up synthetic biology as a promising approach to reconstitute complex dynamics and spatial cues in vitro.