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Journal Article

The roles of microtubule-based transport at presynaptic nerve terminals.

MPS-Authors
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Yagensky,  O.
Research Group of Protein Trafficking in Synaptic Development and Function, MPI for Biophysical Chemistry, Max Planck Society;

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Kalantary Dehaghi,  T.
Research Group of Protein Trafficking in Synaptic Development and Function, MPI for Biophysical Chemistry, Max Planck Society;

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Chua,  J. J. E.
Research Group of Protein Trafficking in Synaptic Development and Function, MPI for Biophysical Chemistry, Max Planck Society;

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2259598.pdf
(Publisher version), 411KB

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Citation

Yagensky, O., Kalantary Dehaghi, T., & Chua, J. J. E. (2016). The roles of microtubule-based transport at presynaptic nerve terminals. Frontiers in Synaptic Neuroscience, 8: 3. doi:10.3389/fnsyn.2016.00003.


Cite as: http://hdl.handle.net/11858/00-001M-0000-002A-0AB1-E
Abstract
Targeted intracellular movement of presynaptic proteins plays important roles during synapse formation and, later, in the homeostatic maintenance of mature synapses. Movement of these proteins, often as vesicular packages, is mediated by motor complexes travelling along intracellular cytoskeletal networks. Presynaptic protein transport by kinesin motors in particular plays important roles during synaptogenesis to bring newly synthesized proteins to establish nascent synaptic sites. Conversely, movement of proteins away from presynaptic sites by Dynein motors enables synapsenuclear signaling and allows for synaptic renewal through degradation of unwanted or damaged proteins. Remarkably, recent data has indicated that synaptic and protein trafficking machineries can modulate each other’s functions. Here, we survey the mechanisms involved in moving presynaptic components to and away from synapses and how this process supports presynaptic function.