Deutsch
 
Hilfe Datenschutzhinweis Impressum
  DetailsucheBrowse

Datensatz

DATENSATZ AKTIONENEXPORT
Zur Ablage hinzufügen
  Lokale TagsFreigabegeschichteDetailsÜbersicht

Freigegeben
Zeitschriftenartikel

Mice with a fra-1 knock-in into the c-fos locus show impaired spatial but regular contextual learning and normal LTP

MPG-Autoren
/persons/resource/persons95439

Sprengel,  Rolf
Department of Molecular Neurobiology, Max Planck Institute for Medical Research, Max Planck Society;

Externe Ressourcen

http://www.sciencedirect.com/science/article/pii/S0169328X04003225/pdfft?md5=10e8c5eeced602db001941bfa6b70c47&pid=1-s2.0-S0169328X04003225-main.pdf
(beliebiger Volltext)

http://dx.doi.org/10.1016/j.molbrainres.2004.07.004
(beliebiger Volltext)

Volltexte (beschränkter Zugriff)
Für Ihren IP-Bereich sind aktuell keine Volltexte freigegeben.
Volltexte (frei zugänglich)
Es sind keine frei zugänglichen Volltexte in PuRe verfügbar
Ergänzendes Material (frei zugänglich)
Es sind keine frei zugänglichen Ergänzenden Materialien verfügbar
Zitation

Gass, P., Fleischmann, A., Hvalby, Ø., Jensen, V., Zacher, C., Strekalova, T., et al. (2004). Mice with a fra-1 knock-in into the c-fos locus show impaired spatial but regular contextual learning and normal LTP. Molecular Brain Research, 130(1), 16-22. doi:10.1016/j.molbrainres.2004.07.004.


Zitierlink: https://hdl.handle.net/11858/00-001M-0000-002A-18A0-3
Zusammenfassung
The immediate early gene c-fos is part of the AP-1 transcription factor complex, which is involved in molecular mechanisms underlying learning and memory. Mice that lack c-Fos in the brain show impairments in spatial reference and contextual learning, and also exhibit a reduced long-term potentiation of synaptic transmission (LTP) at CA3-to-CA1 synapses. In the present study, we investigated mice in which c-fos was deleted and replaced by fra-1 (c-fos(fra-1) mice) to determine whether other members of the c-fos gene family can substitute for the functions of the c-fos gene. In c-fos(fra-1) mice, both CA3-to-CA1 LTP and contextual learning in a Pavlovian fear conditioning task were similar to wild-type littermates, indicating that Fra-1 expression restored the impairments caused by brain-specific c-Fos depletion. However, c-Fos-mediated learning deficits in a reference memory task of the Morris watermaze were also present in c-fos(fra-1) mice. These findings suggest that different c-Fos target genes are involved in LTP, contextual learning, and spatial reference memory formation.