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Journal Article

Restarting life: Fertilization and the transition from meiosis to mitosis


Schuh,  M.
Department of Meiosis, MPI for Biophysical Chemistry, Max Planck Society;

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Clift, D., & Schuh, M. (2013). Restarting life: Fertilization and the transition from meiosis to mitosis. Nature Reviews Molecular Cell Biology, 14(9), 549-562. doi:10.1038/nrm3643.

Cite as: https://hdl.handle.net/11858/00-001M-0000-002A-1F62-6
Fertilization triggers a complex cellular programme that transforms two highly specialized meiotic germ cells, the oocyte and the sperm, into a totipotent mitotic embryo. Linkages between sister chromatids are remodelled to support the switch from reductional meiotic to equational mitotic divisions; the centrosome, which is absent from the egg, is reintroduced; cell division shifts from being extremely asymmetric to symmetric; genomic imprinting is selectively erased and re-established; and protein expression shifts from translational control to transcriptional control. Recent work has started to reveal how this remarkable transition from meiosis to mitosis is achieved.