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Cell-substrate impedance fluctuations of single amoeboid cells encode cell-shape and cell-substrate adhesion dynamics.

MPG-Autoren
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Höppner,  N.
Laboratory for Fluid Dynamics, Pattern Formation and Biocomplexity, Max Planck Institute for Dynamics and Self-Organization, Max Planck Society;

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Tarantola,  M.
Laboratory for Fluid Dynamics, Pattern Formation and Biocomplexity, Max Planck Institute for Dynamics and Self-Organization, Max Planck Society;

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Beta,  C.
Laboratory for Fluid Dynamics, Pattern Formation and Biocomplexity, Max Planck Institute for Dynamics and Self-Organization, Max Planck Society;

Externe Ressourcen

https://journals.aps.org/pre/abstract/10.1103/PhysRevE.93.012414
(Verlagsversion)

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Zitation

Leonhardt, H., Gerhardt, M., Höppner, N., Krüger, K., Tarantola, M., & Beta, C. (2016). Cell-substrate impedance fluctuations of single amoeboid cells encode cell-shape and cell-substrate adhesion dynamics. Physical Review E, 93(1): 012414. doi:10.1103/PhysRevE.93.012414.


Zitierlink: https://hdl.handle.net/11858/00-001M-0000-002A-273C-E
Zusammenfassung
We show systematic electrical impedance measurements of single motile cells on microelectrodes. Wild-type cells and mutant strains were studied that differ in their cell-substrate adhesion strength. We recorded the projected cell area by time-lapse microscopy and observed irregular oscillations of the cell shape. These oscillations were correlated with long-term variations in the impedance signal. Superposed to these long-term trends, we observed fluctuations in the impedance signal. Their magnitude clearly correlated with the adhesion strength, suggesting that strongly adherent cells display more dynamic cell-substrate interactions.