English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT

Released

Journal Article

Anterior cingulate Glutamate-Glutamine cycle metabolites are altered in euthymic bipolar I disorder

MPS-Authors
/persons/resource/persons84402

Henning,  A
Research Group MR Spectroscopy and Ultra-High Field Methodology, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Max Planck Institute for Biological Cybernetics, Max Planck Society;

Fulltext (restricted access)
There are currently no full texts shared for your IP range.
Fulltext (public)
There are no public fulltexts stored in PuRe
Supplementary Material (public)
There is no public supplementary material available
Citation

Soeiro-de-Souza, M., Henning, A., Machado-Vieira, R., Moreno, R., Pastorello, B., da Costa Leite, C., et al. (2015). Anterior cingulate Glutamate-Glutamine cycle metabolites are altered in euthymic bipolar I disorder. European Neuropsychopharmacology, 25(12), 2221-2229. doi:10.1016/j.euroneuro.2015.09.020.


Cite as: https://hdl.handle.net/11858/00-001M-0000-002A-4378-8
Abstract
Bipolar disorder (BD) has been consistently associated with abnormalities in the Glutamate/GABA-Glutamine cycle. Magnetic resonance spectroscopy (MRS) studies have reported increased brain glutamate (Glu) and Glx (Glu+Glutamine) in subjects with BD. However, data on separate measures of GABA and glutamine (Gln) in BD are sparse due to overlapping resonant signals. The development of new sequence methods in the quantification of these metabolites has allowed a better understanding of the Glu/GABA-Gln cycle but data on this field of research remains sparse in BD. Eighty-eight subjects (50 euthymic BD and 38 HC) underwent 3T proton magnetic resonance spectroscopy (1H-MRS) in the anterior cingulate cortex (ACC; 2×2×4.5 cm3) using a two-dimensional JPRESS sequence. GABA, glutamine (Gln) and glutamate (Glu) were quantified with the ProFit program. Using image segmentation and known creatine (Cre) concentrations for white and grey matter, metabolite concentrations were calculated for the excited MRS voxel.