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Improved liposomes-based Ca(II) responsive MRI contrast agents

MPS-Authors
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Vibhute,  S
Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Research Group MR Neuroimaging Agents, Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Gündüz,  S
Max Planck Institute for Biological Cybernetics, Max Planck Society;
Research Group MR Neuroimaging Agents, Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Logothetis,  NK
Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Research Group MR Neuroimaging Agents, Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Angelovski,  G
Max Planck Institute for Biological Cybernetics, Max Planck Society;
Research Group MR Neuroimaging Agents, Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Citation

Garello, F., Vibhute, S., Gündüz, S., Logothetis, N., Angelovski, G., & Terreno, E. (2015). Improved liposomes-based Ca(II) responsive MRI contrast agents. Poster presented at 23rd Annual Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2015), Toronto, Canada.


Cite as: http://hdl.handle.net/11858/00-001M-0000-002A-45E9-7
Abstract
This contribution reports a methodology that enables the preparation of paramagnetic liposomes loaded with an amphiphilic ligand capable to coordinate selectively and sequentially Gd(III) and Ca(II) ions, respectively. The presence of Gd(III) imparts the ability to generate MRI contrast, which is remarkably boosted (ca. 400) by the coordination of Ca(II), thus improving the calcium responsiveness of the nanoprobes with respect similar agents previously investigated.