Necessity of tissue volume composition correction for internal referencing

Zoelch, N; Hock, A; Scheidegger, M; Hulka, L; Quednow, B; Henning, A

Item

ITEM ACTIONSEXPORT

Add to Basket

Local TagsRelease HistoryDetailsSummary

Released

Poster

Necessity of tissue volume composition correction for internal referencing

MPS-Authors

/persons/resource/persons84402

Henning, A
Research Group MR Spectroscopy and Ultra-High Field Methodology, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Max Planck Institute for Biological Cybernetics, Max Planck Society;

External Resource

http://www.ismrm.org/15/program_files/WedTP03.htm
(Publisher version)

Fulltext (restricted access)

There are currently no full texts shared for your IP range.

Fulltext (public)

There are no public fulltexts stored in PuRe

Supplementary Material (public)

There is no public supplementary material available

Citation

Zoelch, N., Hock, A., Scheidegger, M., Hulka, L., Quednow, B., & Henning, A. (2015). Necessity of tissue volume composition correction for internal referencing. Poster presented at 23rd Annual Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2015), Toronto, Canada.

Cite as: https://hdl.handle.net/11858/00-001M-0000-002A-45EF-C

Abstract

The goal of this work was to investigate absolute quantification of brain metabolites in heterogeneous voxels using internal references. To obtain reliable concentrations in heterogeneous voxels, it is necessary to include corrections for the different concentrations as well as different relaxation properties in grey matter, white matter and cerebrospinal fluid of the reference compound. Absolute concentrations were determined in 18 healthy volunteers either by using the internal water as reference or internal creatine and applying the commonly used corrections. A good agreement between the mean concentrations obtained with both reference standards could be only observed when the commonly used corrections are applied. However the correlation between these concentrations compared to correlation of the simple peak area ratios was decreased.