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Single Venule Multi-Echo Line-Scanning fMRI (MELS-fMRI)

MPS-Authors
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He,  Y
Max Planck Institute for Biological Cybernetics, Max Planck Society;
Research Group Translational Neuroimaging and Neural Control, Max Planck Institute for Biological Cybernetics, Max Planck Society;

/persons/resource/persons84805

Merkle,  H
Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Max Planck Institute for Biological Cybernetics, Max Planck Society;

/persons/resource/persons133486

Yu,  X
Max Planck Institute for Biological Cybernetics, Max Planck Society;
Research Group Translational Neuroimaging and Neural Control, Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Citation

He, Y., Merkle, H., & Yu, X. (2015). Single Venule Multi-Echo Line-Scanning fMRI (MELS-fMRI). In 23rd Annual Meeting and Exhibition of the International Society for Magnetic Resonance in Medicine (ISMRM 2015).


Cite as: http://hdl.handle.net/11858/00-001M-0000-002A-4614-0
Abstract
In contrast to the traditional T2*-weighted EPI-fMRI signal, the T2* fMRI signal is more specific with less temporal noise interference. We developed a multi-Echo Line-Scanning fMRI (MELS-fMRI) method to map T2* signal in a block design stimulation paradigm with 100ms sampling rate. Individual penetrating venules can be directly identified from the raw image with 100x100¦Ìm spatial resolution. The spatial pattern of single-venule fMRI signal was detected from 3 ms to 20.5 ms with 3.5ms interval. It is the first step to decipher the millisecond scale fMRI signal propagation across cerebrovasculature in the deep layer cortex.