Opportunities and Challenges: Stem Cell-Based Therapy for the Treatment of 
Ischemic Stroke

Tang, Y-H; Ma, Y-Y; Zhang, Z.J; Wang, Y-T; Yang, G-Y

doi:10.1111/cns.12386

Datensatz

DATENSATZ AKTIONENEXPORT

Zur Ablage hinzufügen

Lokale TagsFreigabegeschichteDetailsÜbersicht

Freigegeben

Zeitschriftenartikel

Opportunities and Challenges: Stem Cell-Based Therapy for the Treatment of Ischemic Stroke

MPG-Autoren

/persons/resource/persons192855

Tang, Y-H
Department High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Max Planck Society;

Externe Ressourcen

http://onlinelibrary.wiley.com/doi/10.1111/cns.12386/pdf
(Verlagsversion)

Volltexte (beschränkter Zugriff)

Für Ihren IP-Bereich sind aktuell keine Volltexte freigegeben.

Volltexte (frei zugänglich)

Es sind keine frei zugänglichen Volltexte in PuRe verfügbar

Ergänzendes Material (frei zugänglich)

Es sind keine frei zugänglichen Ergänzenden Materialien verfügbar

Zitation

Tang, Y.-H., Ma, Y.-Y., Zhang, Z., Wang, Y.-T., & Yang, G.-Y. (2015). Opportunities and Challenges: Stem Cell-Based Therapy for the Treatment of Ischemic Stroke. CNS Neuroscience Therapeutics, 21(4), 337-347. doi:10.1111/cns.12386.

Zitierlink: https://hdl.handle.net/11858/00-001M-0000-002A-46A0-1

Zusammenfassung

Stem cell-based therapy for ischemic stroke has been widely explored in animal models and provides strong evidence of benefits. In this review, we summarize the types of stem cells, various delivery routes, and tracking tools for stem cell therapy of ischemic stroke. MSCs, EPCs, and NSCs are the most explored cell types for ischemic stroke treatment. Although the mechanisms of stem cell-based therapies are not fully understood, the most possible functions of the transplanted cells are releasing growth factors and regulating microenvironment through paracrine mechanism. Clinical application of stem cell-based therapy is still in its infancy. The next decade of stem cell research in stroke field needs to focus on combining different stem cells and different imaging modalities to fully explore the potential of this therapeutic avenue: from bench to bedside and vice versa.