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Journal Article

MRI sensing of neurotransmitters with a crown-ether appended Gd3+ complex

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Oukhatar,  F
Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Logothetis,  NK
Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Angelovski,  G
Research Group MR Neuroimaging Agents, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Max Planck Institute for Biological Cybernetics, Max Planck Society;

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Citation

Oukhatar, F., Même, S., Même, W., Szeremeta, F., Logothetis, N., Angelovski, G., et al. (2015). MRI sensing of neurotransmitters with a crown-ether appended Gd3+ complex. ACS Chemical Neuroscience, 6(2), 219-225. doi:10.1021/cn500289y.


Cite as: http://hdl.handle.net/11858/00-001M-0000-002A-476C-2
Abstract
Molecular MRI approaches that detect biomarkers associated to neural activity would allow more direct observation of brain function than current functional MRI based on blood-oxygen-level-dependent contrast. Our objective was to create a synthetic molecular platform with appropriate recognition moieties for zwitterionic neurotransmitters that generate an MR signal change upon neurotransmitter binding. The gadolinium complex (GdL) we report offers ditopic binding for zwitterionic amino acid neurotransmitters, via: i) interactions between the positively charged and coordinatively unsaturated metal centre and the carboxylate function and ii) between a triazacrown ether and the amine group of the neurotransmitters. GdL discriminates zwitterionic neurotransmitters from monoamines. Neurotransmitter binding leads to a remarkable relaxivity change, related to a decrease in hydration number. GdL was successfully used to monitor neural activity in ex vivo mouse brain slices by MRI.