English
 
Help Privacy Policy Disclaimer
  Advanced SearchBrowse

Item

ITEM ACTIONSEXPORT
Add to Basket
  Local TagsRelease HistoryDetailsSummary

Released
Journal Article

Dendrimeric Calcium-responsive MRI Contrast Agents with Slow in vivo Diffusion

MPS-Authors
/persons/resource/persons192632

Gündüz,  S
Research Group MR Neuroimaging Agents, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Max Planck Institute for Biological Cybernetics, Max Planck Society;

/persons/resource/persons84499

Vibhute,  SM
Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Max Planck Institute for Biological Cybernetics, Max Planck Society;

/persons/resource/persons84063

Logothetis,  NK
Department Physiology of Cognitive Processes, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Max Planck Institute for Biological Cybernetics, Max Planck Society;

/persons/resource/persons83784

Angelovski,  G
Research Group MR Neuroimaging Agents, Max Planck Institute for Biological Cybernetics, Max Planck Society;
Max Planck Institute for Biological Cybernetics, Max Planck Society;

External Resource

http://pubs.rsc.org/en/content/articlepdf/2014/cc/c4cc07540d
(Publisher version)

Fulltext (restricted access)
There are currently no full texts shared for your IP range.
Fulltext (public)
There are no public fulltexts stored in PuRe
Supplementary Material (public)
There is no public supplementary material available
Citation

Gündüz, S., Nitta, N., Vibhute, S., Shibata, S., Maier, M., Logothetis, N., et al. (2015). Dendrimeric Calcium-responsive MRI Contrast Agents with Slow in vivo Diffusion. Chemical Communications, 51(14), 2782-2785. doi:10.1039/C4CC07540D.


Cite as: https://hdl.handle.net/11858/00-001M-0000-002A-4789-F
Abstract
We report a methodology which enables preparation of dendrimeric contrast agents sensitive to Ca2+ when starting from the monomeric analogue. The Ca-triggered longitudinal relaxivity response of these agents is not compromised by undertaken synthetic transformations, despite structural changes. The in vivo MRI studies in rat cerebral cortex indicate that diffusion property of dendrimeric contrast agent has great advantages as compared to its monomeric equivalent.