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Journal Article

Vesicle origami and the influence of cholesterol on lipid packing

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Tassler,  Stephanie
Gerald Brezesinski, Kolloidchemie, Max Planck Institute of Colloids and Interfaces, Max Planck Society;

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Brezesinski,  Gerald
Gerald Brezesinski, Kolloidchemie, Max Planck Institute of Colloids and Interfaces, Max Planck Society;

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Citation

Tanasescu, R., Lanz, M. A., Mueller, D., Tassler, S., Ishikawa, T., Reiter, R., et al. (2016). Vesicle origami and the influence of cholesterol on lipid packing. Langmuir, 32(19), 4896-4903. doi:10.1021/acs.langmuir.6b01143.


Cite as: http://hdl.handle.net/11858/00-001M-0000-002A-4C0E-1
Abstract
The artificial phospholipid Pad-PC-Pad was analyzed in 2D (monolayers at the air/water interface) and 3D (aqueous lipid dispersions) systems. In the gel phase, the two leaflets of a Pad-PC-Pad bilayer interdigitate completely and the the hydrophobic bilayer region has a thickness comparable to the length of a single phospholipid acyl chain. This leads to a stiff membrane with no spontaneous curvature. Forced into a vesicular structure, Pad-PC-Pad shows a faceted geometry and in its extreme form, tetrahedral vesicles were found as predicted a decade ago. Above the main-transition temperature, a non-interdigitated Lα phase with fluid chains has been observed. The addition of cholesterol leads to a slight decrease of the main-transition temperature and a gradual decrease of the transition enthalpy until the transition vanishes at 40 mol% cholesterol in the mixture. Additionally, cholesterol pulls the chains apart and a non-interdigitated gel phase is observed. In monolayers, cholesterol has an ordering effect on liquid-expanded phases and disorders condensed phases. The wavenumbers of the methylene stretching vibration indicate the formation of a liquid-ordered raft phase in mixtures with 40 mol% cholesterol.