Simple convergent-nozzle aerosol injector for single-particle diffractive 
imaging with X-ray free-electron lasers

Kirian, R. A.; Awel, S.; Eckerskorn, N.; Fleckenstein, H.; Wiedorn, M.; Adriano, L.; Bajt, S.; Barthelmess, M.; Bean, R.; Beyerlein, K. R.; Chavas, L. M. G.; Domaracky, M.; Heymann, M.; Horke, D. A.; Knoska, J.; Metz, M.; Morgan, A.; Oberthuer, D.; Roth, N.; Sato, T.; Paulraj, Lourdu Xavier; Yefanov, O.; Rode, A. V.; Küpper, J.; Chapman, H. N.

doi:10.1063/1.4922648

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Simple convergent-nozzle aerosol injector for single-particle diffractive imaging with X-ray free-electron lasers

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Paulraj, Lourdu Xavier
Center for Free-Electron Laser Science, DESY, 22607 Hamburg, Germany;
International Max Planck Research School for Ultrafast Imaging & Structural Dynamics (IMPRS-UFAST), Max Planck Institute for the Structure and Dynamics of Matter, Max Planck Society;
Department of Physics, University of Hamburg, 22761 Hamburg, Germany;

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http://dx.doi.org/10.1063/1.4922648
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Citation

Kirian, R. A., Awel, S., Eckerskorn, N., Fleckenstein, H., Wiedorn, M., Adriano, L., et al. (2015). Simple convergent-nozzle aerosol injector for single-particle diffractive imaging with X-ray free-electron lasers. Structural Dynamics, 2(4): 041717. doi:10.1063/1.4922648.

Cite as: https://hdl.handle.net/11858/00-001M-0000-002A-6035-E

Abstract

A major challenge in high-resolution x-ray free-electron laser-based coherent diffractive imaging is the development of aerosol injectors that can efficiently deliver particles to the peak intensity of the focused X-ray beam. Here, we consider the use of a simple convergent-orifice nozzle for producing tightly focused beams of particles. Through optical imaging we show that 0.5 μm particles can be focused to a full-width at half maximum diameter of 4.2 μm, and we demonstrate the use of such a nozzle for injecting viruses into a micro-focused soft-X-ray FEL beam.