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Boosting of action potential backpropagation by neocortical network activity in vivo

MPG-Autoren
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Waters,  David Jack
Department of Cell Physiology, Max Planck Institute for Medical Research, Max Planck Society;

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Helmchen,  Fritjof
Department of Cell Physiology, Max Planck Institute for Medical Research, Max Planck Society;

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Zitation

Waters, D. J., & Helmchen, F. (2004). Boosting of action potential backpropagation by neocortical network activity in vivo. The Journal of Neuroscience: the Official Journal of the Society for Neuroscience, 24(49), 11127-11136. doi:10.1523/JNEUROSCI.2933-04.2004.


Zitierlink: https://hdl.handle.net/11858/00-001M-0000-002A-617F-F
Zusammenfassung
Action potentials backpropagate into the dendritic trees of pyramidal neurons, reporting output activity to the sites of synaptic input and provoking long-lasting changes in synaptic strength. It is unclear how this retrograde signal is modified by neural network activity. Using whole-cell recordings from somata, apical trunks, and dendritic tuft branches of layer 2/3 pyramidal neurons in vivo, we show that network-driven subthreshold membrane depolarizations ("up states") occur simultaneously throughout the apical dendritic tree. This spontaneous synaptic activity enhances action potential-evoked calcium influx into the distal apical dendrite by promoting action potential backpropagation. Hence, somatic feedback to the dendrites becomes stronger with increasing network activity.