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Journal Article

The primordial, blue-cone color system of the mouse retina

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Dübel,  Jens
Department of Biomedical Optics, Max Planck Institute for Medical Research, Max Planck Society;

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Kuner,  Thomas
Department of Cell Physiology, Max Planck Institute for Medical Research, Max Planck Society;

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Euler,  Thomas
Department of Biomedical Optics, Max Planck Institute for Medical Research, Max Planck Society;

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Citation

Haverkamp, S., Waessle, H., Dübel, J., Kuner, T., Augustine, G. J., Feng, G., et al. (2005). The primordial, blue-cone color system of the mouse retina. The Journal of Neuroscience: the Official Journal of the Society for Neuroscience, 25(22), 5438-5445. doi:10.1523/JNEUROSCI.1117-05.2005.


Cite as: http://hdl.handle.net/11858/00-001M-0000-002A-719F-8
Abstract
Humans and old world primates have trichromatic color vision based on three spectral types of cone [long-wavelength (L-), middle-wavelength (M-), and short-wavelength (S-) cones]. All other placental mammals are dichromats, and their color vision depends on the comparison of L- and S-cone signals; however, their cone-selective retinal circuitry is still unknown. Here, we identified the S-cone-selective (blue cone) bipolar cells of the mouse retina. They were labeled in a transgenic mouse expressing Clomeleon, a chloride-sensitive fluorescent protein, under the control of the thy1 promoter. Blue-cone bipolar cells comprise only 1-2% of the bipolar cell population, and their dendrites selectively contact S-opsin-expressing cones. In the dorsal half of the mouse retina, only 3-5% of the cones express S-opsin, and they are all contacted by blue-cone bipolar cells, whereas all L-opsin-expressing cones (approximately 95%) are avoided. In the ventral mouse retina, the great majority of cones express both S- and L-opsin. They are not contacted by blue-cone bipolar cells. A minority of ventral cones express S-opsin only, and they are selectively contacted by blue-cone bipolar cells. We suggest that these are genuine S-cones. In contrast to the other cones, their pedicles contain only low amounts of cone arrestin. The blue-cone bipolar cells of the mouse retina and their cone selectivity are closely similar to primate blue-cone bipolars, and we suggest that they both represent the phylogenetically ancient color system of the mammalian retina.