Direction-selective dendritic action potentials in rabbit retina

Oesch, Nicholas; Euler, Thomas; Taylor, W. Rowland

doi:10.1016/j.neuron.2005.06.036

Item

ITEM ACTIONSEXPORT

Add to Basket

Local TagsRelease HistoryDetailsSummary

Released

Journal Article

Direction-selective dendritic action potentials in rabbit retina

MPS-Authors

/persons/resource/persons92839

Euler, Thomas
Department of Biomedical Optics, Max Planck Institute for Medical Research, Max Planck Society;

External Resource

http://www.sciencedirect.com/science/article/pii/S089662730500646X/pdfft?md5=540a4baa7153c4e516cdb9aa666fe3ca&pid=1-s2.0-S089662730500646X-main.pdf
(Any fulltext)

http://dx.doi.org/10.1016/j.neuron.2005.06.036
(Any fulltext)

Fulltext (restricted access)

There are currently no full texts shared for your IP range.

Fulltext (public)

There are no public fulltexts stored in PuRe

Supplementary Material (public)

There is no public supplementary material available

Citation

Oesch, N., Euler, T., & Taylor, W. R. (2005). Direction-selective dendritic action potentials in rabbit retina. Neuron, 47(5), 739-750. doi:10.1016/j.neuron.2005.06.036.

Cite as: https://hdl.handle.net/11858/00-001M-0000-002A-C4D4-6

Abstract

Dendritic spikes that propagate toward the soma are well documented, but their physiological role remains uncertain. Our in vitro patch-clamp recordings and two-photon calcium imaging show that direction-selective retinal ganglion cells (DSGCs) utilize orthograde dendritic spikes during physiological activity. DSGCs signal the direction of image motion. Excitatory subthreshold postsynaptic potentials are observed in DSGCs for motion in all directions and provide a weakly tuned directional signal. However, spikes are generated over only a narrow range of motion angles, indicating that spike generation greatly enhances directional tuning. Our results indicate that spikes are initiated at multiple sites within the dendritic arbors of DSGCs and that each dendritic spike initiates a somatic spike. We propose that dendritic spike failure, produced by local inhibitory inputs, might be a critical factor that enhances directional tuning of somatic spikes.